高雄醫學大學醫學研究所 博士

中國醫藥大學附設醫院 助理研究員

上海交通大學醫學院單細胞組學與疾病研究中心 訪問學者

中國醫藥大學附設醫院 博士後研究員

細胞分子生物學

蛋白質體學

腫瘤免疫學

CAR-T與CAR-NK細胞免疫治療

腫瘤微環境

標靶抗體藥物設計與開發

脂質奈米微粒核酸 (LNP-mRNA)藥物開發

1. Lee CP, Ko AM, Nithiyanantham S, Lai CH, Ko YC.  Long noncoding RNA HAR1A regulates oral cancer progression through the alpha-kinase 1, bromodomain 7, and myosin IIA axis.. JOURNAL OF MOLECULAR MEDICINE-JMM. Vol.99:1323-1334. Jun. 2022. (SCI/SCIE)
2. Velmurugan BK, Hua CH, Tsai MH, Lee CP, Chung CM, Ko YC.  Combination of celecoxib and calyculin-A inhibits epithelial-mesenchymal transition in human oral cancer.. BIOTECHNIC & HISTOCHEMISTRY. Vol.95:341-348. Jun. 2020. (SCI/SCIE)
3. Hung CC, Lee CH, Ko AM, Lane HY, Lee CP, Ko YC.  Effect of antidepressants for cessation therapy in betel-quid use disorder: a randomised, double-blind, placebo-controlled trial.. Epidemiology and Psychiatric Sciences. Vol.29:ee125. May. 2020. (SCI/SCIE)
4. Lee CP, Nithiyanantham S, Hsu HT, Yeh KT, Kuo TM, Ko YC.  ALPK1 regulates streptozotocin-induced nephropathy through CCL2 and CCL5 expressions.. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol.23:7699-7708. Nov. 2019. (SCI/SCIE)
5. Kuo TM, Nithiyanantham S, Lee CP, Hsu HT, Luo SY, Lin YZ, Yeh KT, Ko YC.  Arecoline N-oxide regulates oral squamous cell carcinoma development through NOTCH1 and FAT1 expressions.. JOURNAL OF CELLULAR PHYSIOLOGY. Vol.234:13984-13993. Aug. 2019. (SCI/SCIE)
6. Chung CM, Hung CC, Lee CH, Lee CP, Lee KW, Chen MK, Yeh KT, Ko YC.  Variants in FAT1 and COL9A1 genes in male population with or without substance use to assess the risk factors for oral malignancy. PLoS One. Vol.14:ee0210901. Jun. 2019. (SCI/SCIE)
7. Chen PK, Hua CH, Hsu HT, Kuo TM, Chung CM, Lee CP, Tsai MH, Yeh KT, Ko YC.  ALPK1 Expression is associated with lymph node metastasis and tumor growth in oral squamous cell carcinoma patients.. AMERICAN JOURNAL OF PATHOLOGY. Vol.189:190-199. Jun. 2019. (SCI/SCIE)
8. Lee CP, Huang YN, Nithiyanantham S, Huang CM, Ko YC.  LncRNA-Jak3:Jak3 coexpressed pattern regulates monosodium urate crystal-induced osteoclast differentiation through Nfatc1/Ctsk expression.. ENVIRONMENTAL TOXICOLOGY. Vol.34:179-187. Feb. 2019. (SCI/SCIE)
9. Lee CP, Ko AM, Chiang SL, Lu CY, Tsai EM, Ko YC.  Regulatory elements in vectors containing the ctEF-1alpha first intron and double enhancers for an efficient recombinant protein expression system. Scientific Reports. Vol.8:ee15396. Oct. 2018. (SCI/SCIE)
10. Tu HP, Min-Shan Ko A, Lee SS, Lee CP, Kuo TM, Huang CM, Ko YC.  Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout. JOURNAL OF HUMAN GENETICS. Vol.63:63-70. Jun. 2018. (SCI/SCIE)
11. Kuo TM, Huang CM, Tu HP, Min-Shan Ko A, Wang SJ, Lee CP, Ko YC.  URAT1 inhibition by ALPK1 is associated with uric acid homeostasis. RHEUMATOLOGY. Vol.56:654-659. Apr. 2017. (SCI/SCIE)
12. Kuo TM, Hsu HT, Chung CM, Yeh KT, Wu CT, Lee CP, Chiang SL, Huang CM, Ko YC.  Enhanced alpha-kinase 1 accelerates multiple early nephropathies in streptozotocin-induced hyperglycemic mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. Vol.1862:2034-2042. Aug. 2016. (SCI/SCIE)
13. Lee CP, Chiang SL, Ko AM, Liu YF, Ma C, Lu CY, Huang CM, Chang JG, Kuo TM, Chen CL, Tsai EM, Ko YC.  ALPK1 phosphorylates myosin IIA modulating TNF-alpha trafficking in gout flares. Scientific Reports. Vol.6:ee25740. May. 2016. (SCI/SCIE)
14. Lee CP, Chiang SL, Lee CH, Tsai YS, Wang ZH, Hua CH, Chen YC, Tsai EM, Ko YC.  AURKA Phe31Ile polymorphism interacted with use of alcohol, betel quid, and cigarettes at multiplicative risk of oral cancer occurrence.. Clinical Oral Investigations. Vol.19:1825-1832. Feb. 2015. (SCI/SCIE)
15. Kuo TM, Luo SY, Chiang SL, Lee CP, Liu YF,  Chang JG, Tsai MH, d Ko YC.  Arecoline induces TNF alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells.. JOURNAL OF BIOMEDICAL SCIENCE. Vol.21:ee3081. Sep. 2014. (SCI/SCIE)
16. Ko Albert MS, Tu HP, Liu TT, Chang JG, You CY, Chiang SL, Chang SJ, Liu YF, Ko AM, Lee CH, Lee CP, Chang CM, Tsai SF, Ko YC.  ALPK1 genetic regulation and risk in relation to gout.. International Journal of Epidemiology. Vol.42:466-474. Feb. 2013. (SCI/SCIE)
17. Chen PH, Tu HP, Wang SJ, Ko AM, Lee CP, Chiang TA, Tsai YS, Lee CH, Shieh TY, Ko CH, Chiang SL, Ko YC.  Monoamine oxidase A variants are associated with heavy betel quid use.. Addiction biology. Vol.17:786-797. Jul. 2012. (SCI/SCIE)
18. Chen PH, Tu HP, Wang SJ, Ko MS Albert, Lee CP, Chiang TA, Tsai YS, Lee CH, Shieh TY, Ko CH, Chiang SL, Ko YC.  Monoamine oxidase A variants are associated with heavy betel quid use.. Addiction biology. Vol.17:786-797. Jun. 2012. (SCI/SCIE)
19. Nithiyanantham S, Arumugam S, Hsu HT, Chung CM, Lee CP, Tsai MH, Yeh KT, Luo SY, Ko YC.  Arecoline N-oxide initiates oral carcinogenesis and arecoline N-oxide mercapturic acid attenuates the cancer risk.. LIFE SCIENCES. Vol.271:ee119156. Apr. 2012. (SCI/SCIE)
20. Wang SJ, Tu HP, Ko AM, Chiang SL, Chiou SJ, Lee SS, Tsai YS, Lee CP, Ko YC.  Lymphocyte alpha-kinase is a gout-susceptible gene involved in monosodium urate monohydrate-induced inflammatory responses.. JOURNAL OF MOLECULAR MEDICINE. Vol.12:1241-1251. Dec. 2011. (SCI/SCIE)
21. Wu PF, Chiang TA, Chen MT, Lee CP, Chen PH, Ko AM, Yang KJ, Chang PY, Ke DS, Ko YC.  A characterization of the antioxidant enzyme activity and reproductive toxicity in male rats following sub-chronic exposure to areca nut extracts.. Journal of Hazardous Materials. Vol.178:541-546. Feb. 2010. (SCI/SCIE) ( SDGs3)

chopylee@mmu.edu.tw